Deficient Chaperone-Mediated Autophagy Promotes Lipid Accumulation in Macrophage
نویسندگان
چکیده
منابع مشابه
Lysosome membrane lipid microdomains: novel regulators of chaperone-mediated autophagy.
Chaperone-mediated autophagy (CMA) is a selective mechanism for the degradation of soluble cytosolic proteins in lysosomes. The limiting step of this type of autophagy is the binding of substrates to the lysosome-associated membrane protein type 2A (LAMP-2A). In this work, we identify a dynamic subcompartmentalization of LAMP-2A in the lysosomal membrane, which underlies the molecular basis for...
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www.sciencemag.org (this information is current as of January 22, 2009 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/323/5910/124 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/323/5910/124/DC1 can be foun...
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ژورنال
عنوان ژورنال: Journal of Cardiovascular Translational Research
سال: 2020
ISSN: 1937-5387,1937-5395
DOI: 10.1007/s12265-020-09986-3